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DuoBioX Explore Multi-Parallel Benchtop Glass Bioreactor


 

DuoBioX® Explore is mammalian and microbial cell culture bioreactor system with leading design, excellent performance, complete functions and easy operation. Users only need one computer to control 1 to 8 glass tanks to run independently or in parallel. In this way, it can greatly speed up the process development progress. The DuoBioX® Explore system is best choice for the process development study of cell culture in the biopharmaceutical industry.

 

DuoBioX Explore Parallel Bioreactor

 

DuoBioX Explore Parallel BioreactorConcept of design

 

The DuoBioX® Explore system fully meets the requirements of bioreactor technology for biopharmaceuticals applications. The process software uses a concise design language which is easy-to-operate. The complete set of electrical components of the controller are from industry leading suppliers and highly integrated with small footprint, saving your precious benchtop space.

 

DuoBioX Explore Parallel BioreactorMaterial of construction

 

The stainless steel parts of the tank in contact with the liquid are made of SUS316L stainless steel, and the inert surface is easy to clean due to electrolytic polishing. The glass body of the tank is made of high quality tempered borosilicate glass, and the sealing material is made of EPDM or silica gel that meets the requirements of FDA. The non-liquid contact part is made of high quality SUS304 stainless steel.

 

DuoBioX Explore Parallel BioreactorHardware

 

Integrate a full set of hardware from industry leading suppliers, ensures stable and reliable system performance:


 

Ÿ Germen SIEMENS S-1200 series PLC

Ÿ Swiss METTLER TOLEDO pH gel sensor

Ÿ Swiss HAMILTON DO optical sensor

Ÿ UK Watson-Marlow variable speed peristaltic pump

Ÿ Japan Panasonic servo stirring motor

Ÿ Japanese SMC solenoid valve

Ÿ US Dwyer rotameter

Ÿ US ALICAT mass flow meter


DuoBioX Explore Parallel Bioreactor

DuoBioX Explore Parallel BioreactorAdvantages

 

Ÿ Multiple tank specification options, including 500 mL, 3 L, 7 L and 15 L.

Ÿ Satellite design provides great flexibility for system expansion, quickly realize multi-connection or parallel control of 1 to 8 tanks, DuoBioX® Explore system can easily realize parameter setting, process program calling, data backup, and can compare and analyze the trend of different batches under the same interface.

Ÿ Powerful software functions can realize full control based on feedback, time, conditions and script recipes, which can meet the strict process requirements.

Ÿ The operating system developed based on the WinCC industrial-grade architecture meets the requirements of GMP and 21 CFR Part 11, and can be used in pharmaceutical and medical industries.

Ÿ Complete network communication interface, docking with SCADA to realize data collection and remote monitoring.

Ÿ In addition to basic DO, pH, temperature, liquid level, stirring control unit, the system can provide up to three gas supply channels, including overlay gas supply, macro-sparge bottom gas supply and micro-sparge bottom gas supply, allowing users to design flexible air supply strategy, and easily support high-density perfusion cell culture process; the optimized exhaust gas cooling device can effectively prevent clogging, and is compatible with fermentation/high-density cell culture.

Ÿ The controller is designed with 2 additional input ports, which can be connected to sensors, such as sensors of cell density, CO2 and weighing, and additional signals can be integrated in control loop.

 

DuoBioX Explore Parallel Bioreactor


Model

Explore 500 mL

Explore 3 L

Explore 7 L

Explore 15 L

Function

Mammalian cell culture (compatible with microorganisms), control up to 8 tanks

Tank

Working volume

400 mL

2 L

5 L

10 L

Max working volume

500 mL

3.1 L

6.8 L

15 L

Min working volume

100 mL

0.6 L

1.5 L

3.2 L

Aspect ratio

2:1

1.9:1

2.2:1

Np value

1.5

Blade

3 pitched blades 45°

Blade diameter

35 mm

45 mm

60 mm

75 mm

Gas supply tube diameter

4 mm

6 mm

8 mm

8 mm

Macro-sparge diameter

0.5 mm

1 mm

Macro-sparge number

3

5

7

9

Micro-sparge pore size

none

5 μm for optional

Controller

pH sensor

Inpro3100i/SG/ 225

Inpro3100i/SG/ 325

Inpro3100i/SG/ 425

DO sensor

243666-142/225(optical)H2

243666-142/325 (optical) H2

243666-142/425 (optical)H2

CO2 sensor

Optional

Overlay

Rotor flow meter (MFC for optional)

MFC-Air

0~0.1 L

0~0.5 L

0~1 L

0~3 L

MFC-O2

0~0.1 L

0~0.5 L

0~1 L

0~3 L

MFC-CO2

0~0.1 L

0~0.1 L

0~0.5 L

0~1 L

MFC-N2

Optional

MFC-O2 micro sparge

0~0.1 for optional

0~0.5 for optional

0~1 for optional

Built-in peristaltic pump

4xWaston   Malow 114Dvariable speed pump

Temperature control

Electric heating base 100w

Cold water solenoid valve

Exhaust gas cooling

none

Semiconductor or water cooling

Weighting

Optional

Control software (need to be installed on user's computer)

21 CFR Part 11

Yes

Data record

Yes

User authorization management

4 levels

Utilities requirements

Gas source

Air, O2, CO2

Gas source pressure

0.2-0.3   MPa

Control cabinet power supply

220 v 50 Hz

Power socket

10A   three-hole

Cabinet dimension

Length*width*height

554*188*404 mm

Single tank external dimensions

Height*diameter 357*100 mm

Height*diameter 430*210 mm

Height*diameter 510*250 mm

Height*diameter 690*280 mm

Cabinet net weight

45 kg

Tank net weight

2 kg

8 kg

11 kg

15 kg




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