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  • Stainless Steel Microbial Fermentation System
  • Stainless Steel Microbial Fermentation System
  • Stainless Steel Microbial Fermentation System
  • Stainless Steel Microbial Fermentation System

Stainless Steel Microbial Fermentation System


With years of manufacturing experience, Duoning provides customers with 15 L, 30 L, 50 L, 100 L modular-designed pilot-scale system for microbial fermentation, and customized >200 L production-scale fermentation system. The pilot fermentation systems are widely used in the culture of bacteria, cocci, filamentous bacteria, plant cells, yeast, for optimizing the conditions for large-scale production process, or for clinical material manufacturing. The expert team can provide customers with process design, pipeline construction, system integration and manufacturing, control software development and other services.

 

System Features

Ÿ   Modular design, space saving, small footprint;

Ÿ   Sterilization-in-place, easy to use, labor saving;

Ÿ   Equipped with in-place sampling valve for aseptic sampling;

Ÿ   The rational use of axial flow impeller and radial flow impeller provides a high oxygen transfer rate to ensure the demand for high-density culture;

Ÿ   Electric heating for temperature control, achieving rapid heating and cooling, suitable for the production of temperature-induced products;

Ÿ   Enables remote monitoring and communication;

Ÿ   Temperature control using jacket and tank internal dual PID control loop, achieving stable temperature control, high accuracy within ±0.1℃;

Ÿ   Pin type feeding port, easy to use, optional for sterilization-in-place feeding valve group;

Ÿ   Standard configuration with rotameter, optional air/oxygen mixer and mass flowmeter;

Ÿ   Air intake/exhaust filter sterilization can be carried out independently to meet the requirements of filter replacement during the culture process;

Ÿ   Pipeline and frame adopt open design, easy to use and maintain;

Ÿ   Pipeline adopts 3A standard, comply with GMP and BPE requirements;

Ÿ   All valves or instruments can be switched between automatic and manual mode with one click control on the main screen;

Ÿ   Instrument/valve control mode: manual control mode can be selected in the main control screen - you can manually switch the valve or instrument; Or automatic control mode: PID control can be selected

Ÿ   Dissolved oxygen control: DO can be controlled by selecting AIR/O2 flow rate or stirring speed;

Ÿ   Multi-user authorization: multi-level user authorization with password protection to avoid process parameters and data been arbitrarily modified;

Ÿ   Software allows for parameter setting, display control, parameters monitoring, curve analysis, data storage, and output printing;

Ÿ   Multiple levels of control and viewing authorizations.

 

Technical parameters

Tank body

Total volume

15 L

30 L

50 L

100 L

Working volume

10 L

8-22 L

15-35 L

25 – 72 L

Diameter-height   ratio

1:2.2

1:2.2

1:2.2

1:2.2

Material

316L SS

Head plate

316L SS, 4 pieces

Manufacturing   standard

ASME, PED, GB D1/D2, ISO9001:2000


Material 316L stainless steel; Jacket 304 stainless steel

Polishing accuracy of the surface in contact with the material Ra<0.4

Design pressure: 0.3 MPa, working pressure: 0.25 MPa

Connection configuration: safety glass window, side view window, feed valve group port, foam sensor port, pressure sensor port, in-place sampling port, air intake port, bottom valve, inoculation valve group port, base feed port, safety bursting disc

Stir

Type

Top stir, mechanical seal, PID control

Display

Digital display, ±1 rpm

Stir speed

25~800 rpm, ±1 rpm

Impeller

Six-blade impeller

Detection probe

pH

2~12, PID control, accuracy: ±0.01, correlate with base and acid feed pump

DO

0~200%, PID control, accuracy: ±1%, correlate with gas supply flow rate and stir speed (optional)

Liquid level

SS probe, PID control

Temperature

Pt100, PID Control, Digital display, ±0.1℃

Gas control

Flowrate measurement

Thermal mass flow controller (optional)

Gas

Four-gas control   system (N2, O2, CO2, Air) , solenoid valve control

Intake filter

0.2 μm, PTFE

Exhaust filter

0.2 μm, PTFE

Exhaust condenser

316L SS

Pressure regulation

Automatic pressure regulating system, including pressure sensor, and regulating valve

Liquid feed

Peristaltic pump

Variable speed pump, and flow is accumulated,

Temperature

Control method

PID, Automatic sterilization; The temperature is controlled by the external heater and the cooling water under the control of the control system

Control accuracy

Display accuracy: 0.1℃, control accuracy: ±0.1℃

Control range

5 ℃~65 ℃ above cooling water temperature

Control system


Siemens programmable logic controllers for industrial use

Optional configurations


Weighing, tank lid automatic lifting

Water, electricity, gas requirements


Cooling water pressure: 0.15MPa

Cooling water temperature: not higher than 30 ℃

Input air pressure: 0.2MPa (subject to drying and pre-filtration)

Input steam pressure: 0.18MPa (must be pre-filtered)

For more information about custom systems, please contact your local representatives or technical support team of Duoning.

 

 

 


Contact Us
  • Tel.: +86 021 6434 0155
  • E-Mail: marketing@duoningbio.com
  • Address: Building 30, No. 1525 Minqiang Road, Songjiang District, Shanghai
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