As the pharmaceutical industry develops, manufacturing scales and the number of batches are increasing. Traditional manual methods can no longer meet the current requirements for bulk filling. The fully automated bulk filling system can achieve rapid filling and audit-matching data recording. It solves the problem of quickly performing aseptic bulk filling in clean rooms and provides a better solution for subsequent product data audit tracking.
Product Benefits:
Single-use and fully closed design. No valve, less hold up;
Gravimetric method and Flow Rate method supported. Filling accuracy: ±1%;
Flexible recipe editing and parameter setting. The system can automatically recognize weight gain or weight loss filling modes after the parameters are set;
Built-in automatic filtration program: Supports constant flow/constant pressure filtration and sterile filtration operations;
Meet the requirements for research, pilot and commercial scales: suitable for freeze-thaw bags, storage bags, or bottles. All parts of the system can be quickly reassembled;
Compact footprint: Can be placed on a desktop and used within standard laminar flow hoods or ultra-clean workbenches;
The system can be integrated with mixers, weighing system, and power system. Which enhances the automation and intelligence of the filling procedures;
12 reserved sensor ports and 2 network interfaces: Easily integrate on-site instruments or upload data;
The control system complies with GMP requirements and responds quickly, with a startup time less than 1 minute.
System Applications:
Bulk filling
Intermediate filling
Cell culture media filling
Buffer filling
Function Modules:
Sterile Filtration
Exhausting and Purging
Pressure / Flow / Weight Monitoring
Data Integrity
External Devices Communication and Interaction
Main Controller
Interconnectable Modules
Module Connection Interface:
Main Specifications:
Item | Description |
Enclosure material | ABS |
Protection rating | IP54 |
Controller dimensions | 545*420*500 (L*W*H)/mm |
Single container volume | ≥100 mL |
Filling containers | Bags & Bottles |
Bracket | Any form, such as stands, carts, trays, etc. |
Filling accuracy | ±1% *To ensure filling accuracy, the weighing unit accuracy should be better than 0.5% in the weighing filling mode, and the flow meter accuracy should be better than 0.5% in the flow rate filling mode. |
Maximum processes / cycle | 10 +1 (Exhaust and Purge) |
Integrated peristaltic pump maximum flowrate | 3.4 L/min |
Single-use pressure sensor | 0-60 PSI, precision better than 5% |
Clamp-on flowmeter | 0-15 L/min, precision better than 3% |
Printer | Thermal non-adhesive printer |
RJ45 interface | 2 |
Weighting signal input | Any weighing unit supporting serial interface transmission |
System control module | Siemens PLC |
HMI | 13-inch multi-touch industrial computer |
Operation method | Finger touch/active stylus/VNC remote operation |
Data storage | Encrypted database, storage capacity ≥10 years |
Authorization | 9-level user management, customizable user group authorization |
Domain account management | Yes |
Audit trail | Yes |
Electronic signature | Yes |
Recipe management | Yes |
Online calibration | Yes |
Batch management | Yes |
Alarm and interlock | Yes |
Online backup and recovery | Yes |
Scheduled backup | Yes |
Scada protocol | OPCUA, Modbus TCP/IP |
Report generation | |
Language | Chinese / English |
Power supply | 90-260V AC 50/60Hz 2kW |
Utility | No need for compressed air/purified water/water for injection |
Ordering Information:
Model | Product number | Configuration |
Standard version | DuoFill-A-10 | Standard main controller x1, mixer base x1, bottle/bag tray x1 |
Upgraded version | DuoFill-B-10 | Upgraded main controller x1, mixer base x1, bottle/bag tray x1 |
Relevant Documents
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