DuoBioX® Elite is a benchtop fermentation system that supports dual culture modes. Users can quickly establish and develop microbial fermentation processes ranging from 3 to 15 liters with this system, achieving process establishment, development, and optimization with a highly cost-effective investment. The DuoBioX® Elite system is ideal for the early development of fermentation processes in scientific research institutions or the biopharmaceutical industry.
Design Concept
The Elite system fully complies with the technical performance requirements of fermenters in the biopharmaceutical industry. The process software employs a user-friendly design language to facilitate easier operation. The controller features a complete set of high-quality, highly integrated electrical components that occupy minimal space, thereby conserving valuable laboratory benchtop area.
Material of Construction
The stainless-steel parts of the tank body that comes into contact with the liquid is constructed from SUS316L stainless steel and is electropolished to create an inert surface that is easy to clean. The glass tank body is made of high-quality tempered borosilicate glass, while the sealing materials consist of EPDM, silicone, and other substances that comply with FDA requirements. The non-liquid contact parts are made from high-quality SUS304 stainless steel.
System Hardware
Various tank specifications are available, including 3L, 5L, 7L, 15L and more.
The software is powerful and capable of comprehensive control based on feedback, time, conditions, and script recipes, effectively meeting the user's stringent process requirements.
The operating system, developed on the WinCC industrial-grade architecture, complies with GMP and 21 CFR Part 11 regulations, making it suitable for use in industries such as pharmaceuticals and medical devices. The integrated touch HMI kit allows for real-time control of process parameters.
In addition to DO, pH, temperature, liquid level, and stirring control units, users can implement more flexible and variable ventilation strategies to effectively support high-density fermentation and cultivation processes. The optimized cooling coil device enables efficient and precise temperature control using a cooling water medium.
The controller is designed with additional input interfaces to connect various sensors, including those for biomass measurement, weighing, and exhaust analysis. Furthermore, additional sensors can be integrated into the control feedback system.
Model | Elite 3L-F | Elite 5L-F | Elite 7L-F | Elite 15L-F |
Function | Microorganisms, 1 control 1 or 1 control 2 | |||
Tank (with baffle) | ||||
Nominal volume | 3 L | 5 L | 7 L | 15 L |
Max. working volume | 2.2 L | 3.6 L | 5.0 L | 10.8 L |
Min. working volume | 600 mL | 1.2 L | 1.7 L | 3.6 L |
H-to-D ratio (H:D) | 2:1 | 1.8:1 | 2.2:1 | 2:1 |
Number of impellers | 2 | 3 | ||
Impeller type | 6 straight blades x2 | 6 straight blades in the middle and lower layers x2, 6 45° inclined blades in the upper layers x1 | ||
Impeller diameter | 65 mm | 72 mm | 72 mm | 86 mm |
Vent pipe diameter | 4 mm | 6 mm | 8 mm | 8 mm |
Bottom vent diameter | 0.8 mm | |||
Number of vent holes | 8 | 8 | 8 | 16 |
Bottom vent pipe shape | Ring vent pipe | |||
Controller | ||||
pH sensor | 405-DPAS-SC-K8S/225 | 405-DPAS-SC-K8S/325 | ||
DO sensor | 243666-142/225 (optical) H2 | 243666-142/325 (optical) H2 | ||
Reserved external interface | 2* 4-20 mA analog Input | |||
Overlay vent | Air-Rotameter, Oxygen-Rotameter, or optional | |||
MFC-Air | 0-1 L | 0-4 L | 0-10 L | 0-20 L |
MFC-O2 | 0-1 L | 0-4 L | 0-10 L | 0-20 L |
MFC-CO2 | Optional | |||
MFC-N2 | Optional | |||
Liquid level sensor | Standard | |||
Peristaltic pump | 4 built-in, variable speed | |||
Temperature control | Pt100 temperature electrode Electric blanket PID control cold water valve adjustment | |||
Exhaust gas condensation | Cooling water circulation | |||
Weighting | Optional | |||
Control software | ||||
21 CFR Part 11 | Yes | |||
Data record | Yes | |||
User level | 4 Levels | |||
Utility requirements | ||||
Air source | Air , O2, CO2 , N2 | |||
Air source pressure | 0.2-0.3 MPa | |||
Power supply | 220 v 50 Hz | |||
Socket | 10A Three-hole | |||
Control cabinet dimension | Length*Width*Height 520*350*618 mm | |||
Tank body dimension | Height*Diameter (external) 431*200 mm | Height*Diameter (external) 480*250 mm | Height*Diameter (external) 550*250 mm | Height*Diameter (external) 662*340 mm |
I/O cabinet weight | 45 kg | |||
Tank body net weight | 8 kg | 10 kg | 12 kg | 16 kg |
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